This drama is set in a south Florida plastic surgery center, McNamara-Troy, centering around the two doctors who own it. Sean McNamara (Dylan Walsh) is having problems at home, trying to keep his family together, trying to patch up the rocky road him and his wife Julia (Joely Richardson) are experiencing. On the other hand, sex-craved Christian Troy (Julian McMahon) uses his charm to bring in potential female candidates and conducts shady business deals, often for the love of money. While Sean takes his job seriously, he often has to fix Christian's mistakes. During the first season, Sean and Christian got mixed up with Escobar Gallardo, a Colombian drug lord who forced the two to do free surgery whenever he wanted them to. Sean's marriage with Julia began to wear thin, and Sean had an affair with a patient named Megan O'Hara. Julia went back to school, but it was interrupted by a miscarriage of a child Sean and Julia were trying to have. Christian learned he is the father of a baby with a woman named Gina, who he met at Sexaholics Anonymous. When the baby was born, we learn that the baby is African-American, and therefore not his. Julia questions Matt's paternity.

《使女的故事》第二季確定2018年4月回歸，總共會(huì)有13集。

胡鐘秀（潘虹 飾）是一家大型百貸公司的老板，身家數(shù)億，在外人看來能呼風(fēng)喚雨的女強(qiáng)人心中卻有著不為人知的傷痛。丈夫已到天國，生前對(duì)她不忠不義，死后給他留下一雙兒女——患有溝通障礙的兒子姜希宇（李易峰 飾）和反叛的女兒姜希妮（杜十五 飾）。由于姜希宇在住院期間愛上了護(hù)士徐盈（薛凱琪 飾），胡鐘秀請(qǐng)?jiān)洪L做媒，但徐盈不為姜家財(cái)富所動(dòng)，她心里早裝著另外一個(gè)男人韓振宇（李宗翰 飾），而振宇則是希宇爸生前與他人鬼混所生的私生子，胡鐘秀礙于臉面未捅破這層窗戶紙。此時(shí)的徐盈不知道振宇已和他人結(jié)婚，后來得知自已苦等了三年的振宇早已結(jié)婚，徐盈立刻陷入極度悲傷之中，而發(fā)現(xiàn)有機(jī)可乘的胡鐘秀立刻展開撮合行動(dòng)……

西漢宣帝時(shí)期，王夫人和淳于夫人都是后宮女醫(yī)，后二人被利用，最終一個(gè)自盡一個(gè)被問斬。淳于夫人之女淳于瑤（桑葉紅 飾）親眼看著母親和姐姐慘死，由此對(duì)王夫人的女兒王政君（袁立 飾）就此埋下了仇恨種子。十五年后，當(dāng)年的兩個(gè)小女孩都長成了亭亭玉立的少女，王政君和改名為傅瑤的淳于瑤都被選為家人子，同期的家人子還有馮媛（孫茜 飾）、王昭君（白慶林 飾）、李元兒（石小群 飾）。一次偶然的機(jī)會(huì)，五人邂逅了一位老嫗，她預(yù)言說在這五個(gè)女孩中將會(huì)誕生一位皇后。從此，五個(gè)女孩心中都埋下了各自的心事……皇后寶座只有一個(gè)，誰是幸運(yùn)兒？ 當(dāng)年埋下的仇恨是否能夠化解？