This drama is set in a south Florida plastic surgery center, McNamara-Troy, centering around the two doctors who own it. Sean McNamara (Dylan Walsh) is having problems at home, trying to keep his family together, trying to patch up the rocky road him and his wife Julia (Joely Richardson) are experiencing. On the other hand, sex-craved Christian Troy (Julian McMahon) uses his charm to bring in potential female candidates and conducts shady business deals, often for the love of money. While Sean takes his job seriously, he often has to fix Christian's mistakes. During the first season, Sean and Christian got mixed up with Escobar Gallardo, a Colombian drug lord who forced the two to do free surgery whenever he wanted them to. Sean's marriage with Julia began to wear thin, and Sean had an affair with a patient named Megan O'Hara. Julia went back to school, but it was interrupted by a miscarriage of a child Sean and Julia were trying to have. Christian learned he is the father of a baby with a woman named Gina, who he met at Sexaholics Anonymous. When the baby was born, we learn that the baby is African-American, and therefore not his. Julia questions Matt's paternity.

該劇是講述為了達成夢想而努力卻沒有實現(xiàn)夢想的普通人的人生重啟劇，也是再次熱愛滿是挫折的人生并尋找微小卻確實的幸福的“小確幸”電視劇。薛仁雅飾演金清兒，她是一個放棄了戀愛和結(jié)婚，連續(xù)8年準(zhǔn)備考公務(wù)員的公考生，是一個充滿了愛和義氣的人物。金宰英飾演具俊輝，他是一個對他人毫無興趣的不婚主義者，不僅是戀愛，連人際關(guān)系都被他完全切除了，但當(dāng)他遇到金清兒之后開始發(fā)生變化。

該劇講述正在哀悼突然離世的父親的死訊時，此前失蹤的丈夫被人砍斷的手突然出現(xiàn)，打破了平靜，后續(xù)將接二連三地上演一系列連環(huán)殺人案，將聚焦“只要我一個人就好”“差不多就行”“只此一次”的這些想法所誕下的我們那些令人毛骨悚然的沉默時刻，講述在一群為了自己生存下去而保持沉默的人之中，為了活出個人樣而打破沉默的兩個人的故事。

　　這個故事充滿了情感糾葛和人生抉擇的困境。洪峰（林文龍 飾）作為樸實的農(nóng)民，來到廣州投靠父親生前的好友凌淑娥，卻因為誤會而與凌康產(chǎn)生了矛盾。峰決心自立，憑借出色的廚藝開始了自己的生活。然而，凌康野心勃勃，追求高干之女古曉琳，而琳卻愛上了洪峰。情感的錯位和復(fù)雜讓局面更加撲朔迷離。事態(tài)進一步惡化，康竟然誤殺了前度女友，并嫁禍于洪峰，使得洪峰陷入了絕境。為了自救，洪峰和琳逃亡到香港，但途中卻失散了。因時間差異，琳取得身份證，而洪峰卻成為黑市居民，兩人的命運產(chǎn)生了天壤之別。在香港，琳投靠姑姐古冰姑丈符從富，并四處打探洪峰的下落。
　　與此同時，洪峰邂逅了富家女程家寶，寶暗戀著洪峰，并得到兄長家興的支持，但她的父親程大坤卻反對他們的感情。當(dāng)洪峰再次遇到琳時，康也申請到了香港，并發(fā)誓要得到琳。寶對洪峰情根深種，而康為了達到目的，不惜再次陷害洪峰。在這種情況下，洪峰面臨著重重困難和抉擇，他將如何應(yīng)對？在琳和寶之間，他又將做出何種選擇？